Respiratory

Quantitative MRI biomarkers for respiratory function and lung disease studies.

Dynamic contrast-enhanced MRI of the lung showing passage of contrast agent through the pulmonary vasculature.

Bioxydyn offers imaging biomarkers for respiratory diseases such as cystic fibrosis, asthma, pulmonary hypertension, interstitial lung disease (ILD) and COPD. We have been at the forefront of the development and deployment of quantitative MRI methods for assessing lung disease. Our focus is on the use of proton MRI methods that can be deployed on most hospital MRI scanners without substantial investment in specialist hardware or consumables.

Ventilation maps from coronal slices in a cystic fibrosis patient
Ventilation maps from different coronal slices in an adult cystic fibrosis patient. Blue indicates regions receiving oxygen; black regions indicate ventilation defects.

Oxygen-enhanced MRI (OE-MRI) is a non-invasive and non-ionising imaging method that uses oxygen as an MR imaging agent, delivered to the patient in the scanner. OE-MRI can be performed on most hospital scanners.

Lung OE-MRI monitors the delivery of oxygen to a patient's lungs. The acquired quantitative imaging biomarkers relate to regional lung ventilation and gas diffusion. Bioxydyn has extensive experience deploying OE-MRI in diseases including chronic obstructive pulmonary disease (COPD), cystic fibrosis, primary ciliary dyskinesia (PCD), ILD, lung cancer, and asthma.

Dynamic contrast-enhanced MRI of the lung showing passage of contrast agent through the pulmonary vasculature.

Bioxydyn is also a leader in dynamic contrast-enhanced MRI (DCE-MRI) in the lung, providing information on lung perfusion and other microvascular functions, including endothelial permeability and leakage space, in diseases such as pulmonary embolism, asthma, pulmonary hypertension, interstitial lung disease and COPD.

Bioxydyn also provides imaging biomarkers of lung ventilation based on the respiratory motion of the lung over time. These measurements provide ventilation-weighted imaging in a short scan without administration of gases or contrast agents.

Hyperpolarised xenon ventilation MRI parameter maps
Hyperpolarised 129Xe ventilation MRI - example parameter maps.

In addition to conventional (proton) MRI, Bioxydyn provides services to support the use of hyperpolarised 129Xe MRI in studies of lung function. Working with established academic partners, we offer services to support single- and multi-site 129Xe studies investigating ventilation, gas transfer, and pulmonary microstructure.

Bioxydyn offers a range of imaging biomarkers of regional lung function for the assessment of treatment benefit and harm. All can be performed single- or multi-centre using a range of vendors' equipment. Bioxydyn's imaging methods have been validated in multiple studies, including as part of the Innovative Medicines Initiative TRISTAN project funded by the EU.

Publications

Peer-reviewed studies that underpin Bioxydyn respiratory imaging biomarkers, with key publications highlighted.

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13 publications Refine by area, year, or keyword.
  • Contrast enhanced longitudinal changes observed in an experimental bleomycin-induced lung fibrosis rat model by radial DCE-MRI at 9.4T
    2024 Research Article Key Publication

    Contrast enhanced longitudinal changes observed in an experimental bleomycin-induced lung fibrosis rat model by radial DCE-MRI at 9.4T

    In 't Zandt R, Mahmutovic Persson I, Tibiletti M, von Wachenfeldt K, Parker GJM, Olsson LE, et al.

    PLoS One 19(9):e0310643

    Why it matters: Preclinical validation of radial DCE-MRI for longitudinal lung fibrosis monitoring.

    Respiratory
  • Measuring repeatability of dynamic contrast-enhanced MRI biomarkers improves evaluation of biological response to radiotherapy in lung cancer
    2024 Research Article

    Measuring repeatability of dynamic contrast-enhanced MRI biomarkers improves evaluation of biological response to radiotherapy in lung cancer

    Sridharan N, Salem A, Little RA, Tariq M, Cheung S, Dubec MJ, et al.

    Eur Radiol

    OncologyRespiratory
  • Feasibility of dynamic T2*-based oxygen-enhanced lung MRI at 3T
    2024 Research Article

    Feasibility of dynamic T2*-based oxygen-enhanced lung MRI at 3T

    Kim M, Naish JH, Needleman SH, Tibiletti M, Taylor Y, O'Connor JPB, et al.

    Magn Reson Med 91(3):972-986

    Respiratory
  • Independent component analysis applied to dynamic oxygen-enhanced MRI for robust functional lung imaging at 3T
    2024 Research Article

    Independent component analysis applied to dynamic oxygen-enhanced MRI for robust functional lung imaging at 3T

    Needleman SH, Kim M, McClelland JR, Naish JH, Tibiletti M, O'Connor JPB, et al.

    Magn Reson Med 91(3):955-971

    Respiratory
  • Imaging human lung perfusion with contrast media: a meta-analysis
    2023 Meta-analysis

    Imaging human lung perfusion with contrast media: a meta-analysis

    Edwards L, Waterton JC, Naish J, Short C, Semple T, Parker GJ, et al.

    Eur J Radiol 164:110850

    Respiratory
  • Imaging biomarkers of lung ventilation in interstitial lung disease from 129Xe and oxygen-enhanced 1H MRI
    2023 Research Article

    Imaging biomarkers of lung ventilation in interstitial lung disease from 129Xe and oxygen-enhanced 1H MRI

    Tibiletti M, Eaden JA, Naish JH, Hughes PJC, Waterton JC, Heaton MJ, et al.

    Magn Reson Imaging 95:39-49

    Respiratory
  • Evaluation of dynamic contrast-enhanced MRI measures of lung congestion and endothelial permeability in heart failure: a prospective method validation study
    2022 Research Article

    Evaluation of dynamic contrast-enhanced MRI measures of lung congestion and endothelial permeability in heart failure: a prospective method validation study

    Cheriyan J, Roberts A, Roberts C, Graves MJ, Patterson I, Slough RA, et al.

    J Magn Reson Imaging 56(2):450-461

    Respiratory
  • Using imaging to combat a pandemic: rationale for developing the UK National COVID-19 Chest Imaging Database
    2020 Perspective

    Using imaging to combat a pandemic: rationale for developing the UK National COVID-19 Chest Imaging Database

    Jacob J, Alexander D, Baillie JK, Berka R, Bertolli O, Blackwood J, et al.

    Eur Respir J 56(2)

    Respiratory
  • Oxygen-enhanced MRI is feasible, repeatable, and detects radiotherapy-induced change in hypoxia in xenograft models and in patients with non-small cell lung cancer
    2019 Research Article

    Oxygen-enhanced MRI is feasible, repeatable, and detects radiotherapy-induced change in hypoxia in xenograft models and in patients with non-small cell lung cancer

    Salem A, Little RA, Latif A, Featherstone AK, Babur M, Peset I, et al.

    Clin Cancer Res 25(13):3818-3829

    OncologyRespiratory
  • Volumetric dynamic oxygen-enhanced MRI: comparison with CT Brody score and lung function in cystic fibrosis patients
    2018 Research Article

    Volumetric dynamic oxygen-enhanced MRI: comparison with CT Brody score and lung function in cystic fibrosis patients

    Martini K, Gygax CM, Benden C, Morgan AR, Parker GJM, Frauenfelder T

    Eur Radiol 28(10):4037-4047

    Respiratory
  • 2016 Research Article

    T1 relaxation time in lungs of asymptomatic smokers

    Alamidi DF, Kindvall SS, Hubbard Cristinacce PL, McGrath DM, Young SS, Naish JH, et al.

    PLoS One 11(3):e0149760

    Respiratory
    PDF DOI PubMed
  • 2016 Research Article

    T1-weighted dynamic contrast-enhanced MR imaging of the lung in asthma: semiquantitative analysis for the assessment of contrast agent kinetic characteristics

    Zhang WJ, Niven RM, Young SS, Liu YZ, Parker GJ, Naish JH

    Radiology 278(3):906-916

    Respiratory
  • 2015 Research Article

    Dynamic oxygen-enhanced magnetic resonance imaging of the lung in asthma: initial experience

    Zhang WJ, Niven RM, Young SS, Liu YZ, Parker GJ, Naish JH

    Eur J Radiol 84(2):318-326

    Respiratory
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